Patrick Mahomes and the Kansas City Chiefs (4-2) have had a tough schedule to start the 2022 NFL regular season, and it doesn’t get much easier when they travel to San Francisco to take on Jimmy Garoppolo’s 49ers (3-3).
Can Mahomes, Travis Kelce and the Chiefs rebound from a narrow Week 6 loss to the Bills? Or will Garoppolo, Deebo Samuel and San Francisco find a groove at home? There were some who predicted this as a Super Bowl 2023 matchup at the start of this season. The game is set to kick off Sunday at 4:25 p.m. ET from Levi’s Stadium.
Here’s a look at the betting details and USA TODAY’s NFL staff picks for the Chiefs vs. 49ers Week 7 game:
Chiefs at 49ers odds, moneyline and over/under
Follow every game: Live NFL Scores
NFL WEEK 6 DRIP CHECK:Travis Kelce shines brightly; Sauce Gardner embraces the cheesehead
GETTING THERE:Chiefs QB Patrick Mahomes believes rivalry with Josh Allen isn’t yet Brady-Manning level
NEW LIDS:The NFL has returned alternate helmets in 2022: Ranking all 13 from best to worst
Lorenzo Reyes: Chiefs 28, 49ers 23
San Francisco can be so mercurial and I still have the Chiefs as one of the three best teams in the NFL, despite their close loss to the Bills. Kansas City doesn’t tend to lose consecutive games under Andy Reid and Patrick Mahomes and because the Niners’ defense is as banged up as it is, it’s easy to see KC putting up points and covering, despite being on the road.
Safid Deen: Chiefs 27, 49ers 24
Patrick Mahomes threw two interceptions and now faces a vaunted 49ers defense that could be affected if San Francisco star defender Nick Bosa (groin) doesn’t play. Still, I take Mahomes’ firepower over Jimmy Garoppolo’s in this Super Bowl LIV rematch.
Lance Pugmire: 49ers 31, Chiefs 28
Super Bowl revenge for Jimmy G? Yes, the 49ers coughed one up in Atlanta Sunday, but they also watched how Buffalo defended Patrick Mahomes and Co., and the Sunday night game’s in the Bay Area.
NFL WEEK 6 WINNERS AND LOSERS:Bills, Chiefs are top AFC contenders; Bucs struggle in red zone
32 THINGS:Bills bag Chiefs; ‘Who Dey?’ trumps ‘Who Dat?’
IN-DEPTH:The NFL coaches project
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